In 2020-21, the influenza activity in Europe remained at a low level throughout the flu season, due to various public health and social measures implemented to reduce transmission of SARS-CoV-2. However, it is expected that the seasonal influenza virus will circulate much more in the forthcoming winter, as social mixing and social contact now return in many European countries. In addition, because of the low incidence of flu last year, a lower level of natural population immunity against influenza is expected for the 2021-22 season, which could increase transmission and the burden of disease in people.